USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: TOLIP_HUMAN USC-OGP 2-DE database:  TOLIP_HUMAN TOLIP_HUMAN General information about the entry View entry in simple text format Entry name TOLIP_HUMAN Primary accession number Q9H0E2 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Toll-interacting protein;. Gene name Name=TOLLIP Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1233: pI=5.54; Mw=33419 Cross-references UniProtKB/Swiss-Prot Q9H0E2; TOLIP_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TOLIP_HUMAN Primary accession number Q9H0E2 Secondary accession number(s) B3KXC6 Q9H9E6 Q9UJ69 Sequence was last modified on  March 1, 2001 (version 1) Annotations were last modified on  March 15, 2017 (version 150) Name and origin of the protein Description RecName: Full=Toll-interacting protein; Gene name Name=TOLLIP Encoded on Name=TOLLIP Keywords 3D-structure; Acetylation; Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Immunity; Inflammatory response; Innate immunity; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AJ242972; CAB58118.1; -; mRNA EMBL AL136835; CAB66769.1; -; mRNA EMBL AK022871; BAB14283.1; ALT_INIT; mRNA EMBL AK127123; BAG54438.1; -; mRNA EMBL AC136297; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC004420; AAH04420.1; -; mRNA EMBL BC012057; AAH12057.1; -; mRNA EMBL BC018272; AAH18272.1; -; mRNA CCDS CCDS7723.1; -. [Q9H0E2-1]; . CCDS CCDS81532.1; -. [Q9H0E2-2]; . RefSeq NP_001305441.1; NM_001318512.1; . RefSeq NP_001305443.1; NM_001318514.1. [Q9H0E2-2]; . RefSeq NP_001305444.1; NM_001318515.1; . RefSeq NP_001305445.1; NM_001318516.1; . RefSeq NP_061882.2; NM_019009.3. [Q9H0E2-1]; . UniGene Hs.368527; -; . PDB 1WGL; NMR; -; A=229-274 PDB 2N31; NMR; -; A=1-53 PDBsum 1WGL; -; . PDBsum 2N31; -; . ProteinModelPortal Q9H0E2; -; . SMR Q9H0E2; -; . BioGrid 119978; 83; . DIP DIP-30845N; -; . IntAct Q9H0E2; 74; . MINT MINT-4539075; -; . STRING 9606.ENSP00000314733; -; . iPTMnet Q9H0E2; -; . PhosphoSitePlus Q9H0E2; -; . BioMuta TOLLIP; -; . DMDM 20140803; -; . EPD Q9H0E2; -; . MaxQB Q9H0E2; -; . PaxDb Q9H0E2; -; . PeptideAtlas Q9H0E2; -; . PRIDE Q9H0E2; -; . DNASU 54472; -; . Ensembl ENST00000317204; ENSP00000314733; ENSG00000078902. [Q9H0E2-1]; . Ensembl ENST00000527886; ENSP00000434035; ENSG00000078902. [Q9H0E2-2]; . GeneID 54472; -; . KEGG hsa:54472; -; . UCSC uc001ltd.4; human. [Q9H0E2-1]; . CTD 54472; -; . DisGeNET 54472; -; . GeneCards TOLLIP; -; . HGNC HGNC:16476; TOLLIP; . HPA HPA038621; -; . HPA HPA038622; -; . MIM 606277; gene; . neXtProt NX_Q9H0E2; -; . OpenTargets ENSG00000078902; -; . PharmGKB PA134876213; -; . eggNOG ENOG410IE45; Eukaryota; . eggNOG ENOG410XQPY; LUCA; . GeneTree ENSGT00390000013104; -; . HOGENOM HOG000293427; -; . HOVERGEN HBG054213; -; . InParanoid Q9H0E2; -; . KO K05402; -; . OMA HVTIPES; -; . OrthoDB EOG091G0JE1; -; . PhylomeDB Q9H0E2; -; . TreeFam TF324180; -; . Reactome R-HSA-446652; Interleukin-1 signaling; . Reactome R-HSA-6798695; Neutrophil degranulation; . SignaLink Q9H0E2; -; . ChiTaRS TOLLIP; human; . EvolutionaryTrace Q9H0E2; -; . GeneWiki TOLLIP; -; . GenomeRNAi 54472; -; . PRO PR:Q9H0E2; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000078902; -; . CleanEx HS_TOLLIP; -; . ExpressionAtlas Q9H0E2; baseline and differential; . Genevisible Q9H0E2; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0005737; C:cytoplasm; IC:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0045323; C:interleukin-1 receptor complex; NAS:UniProtKB; . GO GO:0045092; C:interleukin-18 receptor complex; NAS:UniProtKB; . GO GO:0016604; C:nuclear body; IEA:Ensembl; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0035580; C:specific granule lumen; TAS:Reactome; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0004871; F:signal transducer activity; NAS:UniProtKB; . GO GO:0035325; F:Toll-like receptor binding; IPI:UniProtKB; . GO GO:0043130; F:ubiquitin binding; IBA:GO_Central; . GO GO:0031624; F:ubiquitin conjugating enzyme binding; IBA:GO_Central; . GO GO:0006914; P:autophagy; IEA:UniProtKB-KW; . GO GO:0007267; P:cell-cell signaling; TAS:ProtInc; . GO GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB; . GO GO:0006954; P:inflammatory response; NAS:UniProtKB; . GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:0035556; P:intracellular signal transduction; NAS:UniProtKB; . GO GO:0045321; P:leukocyte activation; NAS:UniProtKB; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0016310; P:phosphorylation; IDA:UniProtKB; . GO GO:0033235; P:positive regulation of protein sumoylation; IEA:Ensembl; . GO GO:0036010; P:protein localization to endosome; IDA:UniProtKB; . GO GO:0007165; P:signal transduction; IPI:UniProtKB; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central; . Gene3D 2.60.40.150; -; 1; . InterPro IPR000008; C2_dom; . InterPro IPR003892; CUE; . InterPro IPR009060; UBA-like; . Pfam PF00168; C2; 1; . Pfam PF02845; CUE; 1; . SMART SM00239; C2; 1; . SMART SM00546; CUE; 1; . SUPFAM SSF46934; SSF46934; 1; . SUPFAM SSF49562; SSF49562; 1; . PROSITE PS51140; CUE; 1; .

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